displaying: http://wikileaksisdemocracy.org/feed

Wikileaksisdemocracy
Gene mutations that contribute to head and neck cancer also provide ‘precision’ treatment targets
Jeff Goldblum Comparte Pensamientos Después De Ver Jurassic World: Dominion (y Ya Tiene Planes De Volver) – Noticias Del Mundo En Español
Unravelling the origins of the human spine
Sampling the deep graveyard of Earth’s earliest crust
Engineers get under the skin of ionic skin
Ucraina, diretta. Missili su Kiev durante la visita di Guterres. Usa: truppe russe lasciano Mariupol
Neuronal plasticity in chronic pain-induced anxiety revealed
Et si nous étions plus utiles que nous ne l’imaginons ?
Jennifer Lopez y Ben Affleck: cómo se sienten los hijos del actor con su futura boda
Il Mago di Oz, in vendita all’asta il famoso abito di Judy Garland

MagpieRSS Object
(
    [parser] => 0
    [current_item] => Array
        (
        )

    [items] => Array
        (
            [0] => Array
                (
                    [title] => Gene mutations that contribute to head and neck cancer also provide ‘precision’ treatment targets
                    [link] => https://wikileaksisdemocracy.org/healthandscience/gene-mutations-that-contribute-to-head-and-neck-cancer-also-provide-precision-treatment-targets/
                    [dc] => Array
                        (
                            [creator] => Tony Grantly
                        )

                    [pubdate] => Fri, 29 Apr 2022 04:04:53 +0000
                    [category] => Health And SciencecancercontributegenemutationsneckprecisionprovidetargetsTreatment
                    [guid] => https://wikileaksisdemocracy.org/?p=30157
                    [description] => Journal Reference: Hoi-Lam Ngan, Chun-Ho Law, Yannie Chung Yan Choi, Jenny Yu-Sum Chan, Vivian Wai Yan Lui. Precision drugging of the MAPK pathway in head and neck cancer. npj Genomic Medicine, 2022; 7 (1) DOI: 10.1038/s41525-022-00293-1 Keys to targeting that vulnerability include individualized genomic analysis to identify a patient’s specific mutation, and finding the drugs ... Read more
                    [content] => Array
                        (
                            [encoded] => 

Journal Reference:

  1. Hoi-Lam Ngan, Chun-Ho Law, Yannie Chung Yan Choi, Jenny Yu-Sum Chan, Vivian Wai Yan Lui. Precision drugging of the MAPK pathway in head and neck cancer. npj Genomic Medicine, 2022; 7 (1) DOI: 10.1038/s41525-022-00293-1

Keys to targeting that vulnerability include individualized genomic analysis to identify a patient’s specific mutation, and finding the drugs that directly target it, investigations that should be given more attention in cancer therapy development, they report in a review article in the journal NPJ Genomic Medicine.

The MAPK pathway is a “signaling hub” for cells important to the usual development of the head and neck region, and activating key pathway constituents, like the genes MAPK1 and HRAS, is known to drive the growth of a variety of cancers, says Dr. Vivian Wai Yan Lui, molecular pharmacologist and translational scientist at the Georgia Cancer Center and Medical College of Georgia and the paper’s corresponding author.

But the mutations in the genes in the MAPK pathway that enable tumor growth can also make it sensitive to drug therapy, says Lui. While a lot of discovery is still needed to find more mutations in the MAPK pathway and the drugs that target them, Lui says they are among the most logical treatment targets for this tough-to-treat cancer.

As she speaks, she is looking in her lab for drugs that kill head and neck primary tumors from patients, and at the genetics behind how they kill.

“It’s critical to the survival of the cancer,” says Lui, and every cancer type likely has one or more drug-sensitizing mutations that may vary in individuals depending on how they got cancer.

If these types of studies continue to find the methodology works, gene panels might need to be developed to expedite target discovery in this very heterogenous cancer, the scientists write.

More clinical trials around the globe at institutions like MCG and the Georgia Cancer Center are essential to identifying these specific mutations and drugs that target them in a precision manner, Lui notes.

Also, next on the horizon is combining this “precision medicine” approach with immunotherapy that better enables a patient’s immune system to also target the cancer, she says.

Lui’s interest in the MAPK pathway solidified almost a decade ago at the University of Pittsburgh where she did her postdoctoral studies and eventually joined the faculty. Her mentor was Dr. Jennifer R. Grandis (now at the University of California, San Francisco), who led the head and neck cancer program there. The patient in his 30s, a heavy smoker and drinker, had stage four head and neck squamous cell carcinoma that had metastasized to his lymph nodes. The patient went to Pittsburgh for removal of the lymph nodes and the primary tumor but was fortunate enough to be eligible for a “window of opportunity” trial there. Before starting any standard treatment, he received a trial drug for 13 days, in his case an epidermal growth factor receptor, or EGFR, blocker. The receptor is involved in cell growth, and is found on some normal cells, including in the head and neck area where there is a lot of natural cell turnover because of exposure to things like food and drink. However, in cancer cells, including head and neck cancer cells, EGFR is abundantly expressed for the rapid growth critical to a tumor’s spread and survival.

The patient was given the drug, erlotinib, which was not known to be particularly effective in these cancers but was being looked at to see if it would quieten signaling of this factor that was important to the cancer’s growth. When he went for surgery following the trial, the surgeon called to report there was no cancer on his tongue and studies of his 36 lymph nodes indicated they also now showed no evidence of cancer. The patient was still doing well by the time the Pittsburgh colleagues published the paper two years later in 2015 in JAMA Oncology.

His was rightly called an “exceptional response,” the first Lui and her colleagues had found in head and neck cancer, and she had to figure out the mutation the drug targeted to enable such a response. Exceptional responders are how the National Cancer Institute describes people who have more than a six-month response to a therapy when they are running out of treatment options.

An EGFR gene mutation was a logical choice for his mutation. Harvard investigators had previously found that in non-small cell lung cancer, EGFR activating mutations could activate tumor cell growth, which also made tumor cells “addicted” to the signal from the mutated EGFR. The drug erlotinib could break the addiction and inhibit cancer cell growth.

Lui didn’t find an EGFR mutation in this young man’s pretreatment biopsy but reasoned the mutation had to have something to do with the receptor’s signaling network. She was surprised — and the first — to find it was a MAPK1 gene mutation, MAPK1 p.E322K specifically, that could also be found in liver, breast and other cancers.

When they later engineered the mutation in head and neck cancer cells, the already aggressive cells grew even faster, Lui says of a mutation that can result from habits like heavy smoking and drinking. They would also find that the particular mutation was very common in the United States in patients with head and neck cancer, while there was a wider spectrum of mutations present in Asians with the cancer.

Erlotinib had actually failed in clinical trials because it wasn’t given to the right patients, which is what precision medicine is, Lui notes. In fact, laboratory studies had indicated that activation of MAPK1 confers resistance to erlotinib, she says, while this patient’s response clearly counters that. Follow up work by Grandis indicated that in patients actually, the higher the MAPK1 activation, the better the cancer responded to erlotinib.

To help move cancer treatment forward, Lui encourages physicians who come across these types of “exceptional responses” to report them, work with scientists to study them, then pursue clinical trials when appropriate.

For patients, her message is not to give up because with more high-level analysis of tumors, there might be a certain mutation that makes their cancer vulnerable to a specific medication, she says of these “gene-drug responses” that are the focal point of her translational work.

“There are secrets that make the cancer vulnerable,” Lui says. “When cancer cells have an important gene mutation that they are activating or that cancer cells are addicted to for survival, then when you hit that signaling pathway, the cancer cells will die or be really well controlled.”

Prior to the era of genomic medicine, when scientists began to identify and target a specific gene mutation, “non-precision” drug treatment of the MAPK pathway in head and neck cancers as well as other cancers were “futile,” and typically “failed miserably” in clinical trials, Lui and her colleagues write.

While the reasons may be uncertain, they likely include the wrong drug for that specific, problematic mutation, Lui says, as well as the fact that some MAPK pathway mutations are known to convey drug resistance.

Either way, there is a lot of work to do. Today there are just a handful of drugs that target specific, cancer-causing mutations in head and neck cancer but there aren’t effective precision drugs for about 80% of patients, Lui and her coauthors write.

But there is mounting evidence that targeting specific MAPK pathway mutations in the pathway like MAPK1, HRAS, KRAS and BRAF can be very effective for these patients.

As an example, the RAS inhibitor tipifarnib received Breakthrough Therapy Designation by the Food and Drug Administration in February 2021 for patients with a specific recurrent or metastatic HRAS-mutant head and neck squamous cell cancer. HRAS is involved in cell growth signaling.

Also, studies indicate that EGFR targeted therapy in metastatic non-small cell lung cancer, increases progression-free survival to a median of 18.9 months and median overall survival beyond three years and reduces death rates about 52%. In 2016 the Food and Drug Administration modified its approval of erlotinib to treat non-small cell lung cancer patients with the specific EGFR mutations. In 2020, the FDA approved erlotinib in combination with ramucirumab, a monoclonal antibody that binds to a receptor for vascular endothelial growth factor, or VEGF, which tumors use to grow the blood vessels they need to thrive, as a frontline treatment for these cancers. The FDA granted Breakthrough Therapy Designation to tipifarnib, an inhibitor of a protein which has the downstream effect of interfering in this case with mutations of the gene HRAS, which is also involved in cell division and in the MAPK pathway. There are now more than 1.5 million people with non-small cell lung cancer on precision medicine because of investigators who continued to examine the initial few responders, Lui says.

Lui is a native of Hong Kong, who was on the faculty of The Chinese University of Hong Kong before joining the MCG faculty in October 2021. In 2020 Lui and her colleagues reported that MAPK pathway mutations are a factor in about one-fifth of head and neck cancer patients and that “unexpectedly” these mutations are associated with longer patient survival than other causes like human papillomavirus.

Head and neck cancer is typically aggressive and often both the disease and its treatment are painful and disfiguring. It carries a higher risk of suicide than many other cancer types. The incidence of head and neck cancer is going up across the world, with causes including tobacco and/or alcohol use, air pollutants, cancer causing viruses like the sexually transmitted HPV, and Epstein-Barr virus, one of the most common viruses that is primarily spread by saliva and can cause problems like infectious mononucleosis. Other causes include poor dental hygiene and chewing betel nut, a stimulant which comes from the Areca palm plant, and is used as a recreational drug and as a still-unproven treatment for problems like schizophrenia and glaucoma. Chewing betel nut is a common cultural practice in South and Southeast Asia and the Asian Pacific. It’s often chewed with products like tobacco and has been associated with cancer and a host of other medical problems like a slow heart rate and stomach ulcers.

The carcinogens largely damage the lining of the head and neck region resulting in one or more mutations that can lead to cancer.

We would love to give thanks to the author of this write-up for this amazing material

Gene mutations that contribute to head and neck cancer also provide ‘precision’ treatment targets

) [summary] => Journal Reference: Hoi-Lam Ngan, Chun-Ho Law, Yannie Chung Yan Choi, Jenny Yu-Sum Chan, Vivian Wai Yan Lui. Precision drugging of the MAPK pathway in head and neck cancer. npj Genomic Medicine, 2022; 7 (1) DOI: 10.1038/s41525-022-00293-1 Keys to targeting that vulnerability include individualized genomic analysis to identify a patient’s specific mutation, and finding the drugs ... Read more [atom_content] =>

Journal Reference:

  1. Hoi-Lam Ngan, Chun-Ho Law, Yannie Chung Yan Choi, Jenny Yu-Sum Chan, Vivian Wai Yan Lui. Precision drugging of the MAPK pathway in head and neck cancer. npj Genomic Medicine, 2022; 7 (1) DOI: 10.1038/s41525-022-00293-1

Keys to targeting that vulnerability include individualized genomic analysis to identify a patient’s specific mutation, and finding the drugs that directly target it, investigations that should be given more attention in cancer therapy development, they report in a review article in the journal NPJ Genomic Medicine.

The MAPK pathway is a “signaling hub” for cells important to the usual development of the head and neck region, and activating key pathway constituents, like the genes MAPK1 and HRAS, is known to drive the growth of a variety of cancers, says Dr. Vivian Wai Yan Lui, molecular pharmacologist and translational scientist at the Georgia Cancer Center and Medical College of Georgia and the paper’s corresponding author.

But the mutations in the genes in the MAPK pathway that enable tumor growth can also make it sensitive to drug therapy, says Lui. While a lot of discovery is still needed to find more mutations in the MAPK pathway and the drugs that target them, Lui says they are among the most logical treatment targets for this tough-to-treat cancer.

As she speaks, she is looking in her lab for drugs that kill head and neck primary tumors from patients, and at the genetics behind how they kill.

“It’s critical to the survival of the cancer,” says Lui, and every cancer type likely has one or more drug-sensitizing mutations that may vary in individuals depending on how they got cancer.

If these types of studies continue to find the methodology works, gene panels might need to be developed to expedite target discovery in this very heterogenous cancer, the scientists write.

More clinical trials around the globe at institutions like MCG and the Georgia Cancer Center are essential to identifying these specific mutations and drugs that target them in a precision manner, Lui notes.

Also, next on the horizon is combining this “precision medicine” approach with immunotherapy that better enables a patient’s immune system to also target the cancer, she says.

Lui’s interest in the MAPK pathway solidified almost a decade ago at the University of Pittsburgh where she did her postdoctoral studies and eventually joined the faculty. Her mentor was Dr. Jennifer R. Grandis (now at the University of California, San Francisco), who led the head and neck cancer program there. The patient in his 30s, a heavy smoker and drinker, had stage four head and neck squamous cell carcinoma that had metastasized to his lymph nodes. The patient went to Pittsburgh for removal of the lymph nodes and the primary tumor but was fortunate enough to be eligible for a “window of opportunity” trial there. Before starting any standard treatment, he received a trial drug for 13 days, in his case an epidermal growth factor receptor, or EGFR, blocker. The receptor is involved in cell growth, and is found on some normal cells, including in the head and neck area where there is a lot of natural cell turnover because of exposure to things like food and drink. However, in cancer cells, including head and neck cancer cells, EGFR is abundantly expressed for the rapid growth critical to a tumor’s spread and survival.

The patient was given the drug, erlotinib, which was not known to be particularly effective in these cancers but was being looked at to see if it would quieten signaling of this factor that was important to the cancer’s growth. When he went for surgery following the trial, the surgeon called to report there was no cancer on his tongue and studies of his 36 lymph nodes indicated they also now showed no evidence of cancer. The patient was still doing well by the time the Pittsburgh colleagues published the paper two years later in 2015 in JAMA Oncology.

His was rightly called an “exceptional response,” the first Lui and her colleagues had found in head and neck cancer, and she had to figure out the mutation the drug targeted to enable such a response. Exceptional responders are how the National Cancer Institute describes people who have more than a six-month response to a therapy when they are running out of treatment options.

An EGFR gene mutation was a logical choice for his mutation. Harvard investigators had previously found that in non-small cell lung cancer, EGFR activating mutations could activate tumor cell growth, which also made tumor cells “addicted” to the signal from the mutated EGFR. The drug erlotinib could break the addiction and inhibit cancer cell growth.

Lui didn’t find an EGFR mutation in this young man’s pretreatment biopsy but reasoned the mutation had to have something to do with the receptor’s signaling network. She was surprised — and the first — to find it was a MAPK1 gene mutation, MAPK1 p.E322K specifically, that could also be found in liver, breast and other cancers.

When they later engineered the mutation in head and neck cancer cells, the already aggressive cells grew even faster, Lui says of a mutation that can result from habits like heavy smoking and drinking. They would also find that the particular mutation was very common in the United States in patients with head and neck cancer, while there was a wider spectrum of mutations present in Asians with the cancer.

Erlotinib had actually failed in clinical trials because it wasn’t given to the right patients, which is what precision medicine is, Lui notes. In fact, laboratory studies had indicated that activation of MAPK1 confers resistance to erlotinib, she says, while this patient’s response clearly counters that. Follow up work by Grandis indicated that in patients actually, the higher the MAPK1 activation, the better the cancer responded to erlotinib.

To help move cancer treatment forward, Lui encourages physicians who come across these types of “exceptional responses” to report them, work with scientists to study them, then pursue clinical trials when appropriate.

For patients, her message is not to give up because with more high-level analysis of tumors, there might be a certain mutation that makes their cancer vulnerable to a specific medication, she says of these “gene-drug responses” that are the focal point of her translational work.

“There are secrets that make the cancer vulnerable,” Lui says. “When cancer cells have an important gene mutation that they are activating or that cancer cells are addicted to for survival, then when you hit that signaling pathway, the cancer cells will die or be really well controlled.”

Prior to the era of genomic medicine, when scientists began to identify and target a specific gene mutation, “non-precision” drug treatment of the MAPK pathway in head and neck cancers as well as other cancers were “futile,” and typically “failed miserably” in clinical trials, Lui and her colleagues write.

While the reasons may be uncertain, they likely include the wrong drug for that specific, problematic mutation, Lui says, as well as the fact that some MAPK pathway mutations are known to convey drug resistance.

Either way, there is a lot of work to do. Today there are just a handful of drugs that target specific, cancer-causing mutations in head and neck cancer but there aren’t effective precision drugs for about 80% of patients, Lui and her coauthors write.

But there is mounting evidence that targeting specific MAPK pathway mutations in the pathway like MAPK1, HRAS, KRAS and BRAF can be very effective for these patients.

As an example, the RAS inhibitor tipifarnib received Breakthrough Therapy Designation by the Food and Drug Administration in February 2021 for patients with a specific recurrent or metastatic HRAS-mutant head and neck squamous cell cancer. HRAS is involved in cell growth signaling.

Also, studies indicate that EGFR targeted therapy in metastatic non-small cell lung cancer, increases progression-free survival to a median of 18.9 months and median overall survival beyond three years and reduces death rates about 52%. In 2016 the Food and Drug Administration modified its approval of erlotinib to treat non-small cell lung cancer patients with the specific EGFR mutations. In 2020, the FDA approved erlotinib in combination with ramucirumab, a monoclonal antibody that binds to a receptor for vascular endothelial growth factor, or VEGF, which tumors use to grow the blood vessels they need to thrive, as a frontline treatment for these cancers. The FDA granted Breakthrough Therapy Designation to tipifarnib, an inhibitor of a protein which has the downstream effect of interfering in this case with mutations of the gene HRAS, which is also involved in cell division and in the MAPK pathway. There are now more than 1.5 million people with non-small cell lung cancer on precision medicine because of investigators who continued to examine the initial few responders, Lui says.

Lui is a native of Hong Kong, who was on the faculty of The Chinese University of Hong Kong before joining the MCG faculty in October 2021. In 2020 Lui and her colleagues reported that MAPK pathway mutations are a factor in about one-fifth of head and neck cancer patients and that “unexpectedly” these mutations are associated with longer patient survival than other causes like human papillomavirus.

Head and neck cancer is typically aggressive and often both the disease and its treatment are painful and disfiguring. It carries a higher risk of suicide than many other cancer types. The incidence of head and neck cancer is going up across the world, with causes including tobacco and/or alcohol use, air pollutants, cancer causing viruses like the sexually transmitted HPV, and Epstein-Barr virus, one of the most common viruses that is primarily spread by saliva and can cause problems like infectious mononucleosis. Other causes include poor dental hygiene and chewing betel nut, a stimulant which comes from the Areca palm plant, and is used as a recreational drug and as a still-unproven treatment for problems like schizophrenia and glaucoma. Chewing betel nut is a common cultural practice in South and Southeast Asia and the Asian Pacific. It’s often chewed with products like tobacco and has been associated with cancer and a host of other medical problems like a slow heart rate and stomach ulcers.

The carcinogens largely damage the lining of the head and neck region resulting in one or more mutations that can lead to cancer.

We would love to give thanks to the author of this write-up for this amazing material

Gene mutations that contribute to head and neck cancer also provide ‘precision’ treatment targets

) [1] => Array ( [title] => Jeff Goldblum Comparte Pensamientos Después De Ver Jurassic World: Dominion (y Ya Tiene Planes De Volver) – Noticias Del Mundo En Español [link] => https://wikileaksisdemocracy.org/celebrity/jeff-goldblum-comparte-pensamientos-despues-de-ver-jurassic-world-dominion-y-ya-tiene-planes-de-volver-noticias-del-mundo-en-espanol/ [dc] => Array ( [creator] => Sally Scully ) [pubdate] => Fri, 29 Apr 2022 04:04:44 +0000 [category] => CelebritycompartedeldespuésDominionespañolGoldblumJeffJurassicMundoNoticiasPensamientosPlanestienevervolver [guid] => https://wikileaksisdemocracy.org/?p=30152 [description] => Mundo Jurásico: Dominio es sin duda uno de los lanzamientos más esperados de este año. La tercera película en el Mundo franquicia y sexta película de franquicia en general se dirige a la calendario de cine 2022 el 10 de junio. Todavía faltan varias semanas, pero resulta que el elenco ya vio la película completa, ... Read more [content] => Array ( [encoded] =>

Mundo Jurásico: Dominio es sin duda uno de los lanzamientos más esperados de este año. La tercera película en el Mundo franquicia y sexta película de franquicia en general se dirige a la calendario de cine 2022 el 10 de junio. Todavía faltan varias semanas, pero resulta que el elenco ya vio la película completa, y Jeff Goldblum y Bryce Dallas Howard aparecieron en CinemaCon este año para hablar sobre su «infinita gratitud» por la franquicia y compartir su primeras tomas de la película. Ah, y el estreno de la nueva película también será un momento dulce para la familia de Jeff Goldblum.

Antes de compartir algunas imágenes nuevas, Jeff Goldblum y Bryce Dallas Howard hablaron un poco sobre sus experiencias en la icónica franquicia. Para Goldblum, ir al cine siempre ha sido la experiencia más «romántica» y «mágica» para él y parece genuinamente entusiasmado con lo que Dominio está llevando a la gran pantalla.

We would like to say thanks to the author of this short article for this remarkable content

Jeff Goldblum Comparte Pensamientos Después De Ver Jurassic World: Dominion (y Ya Tiene Planes De Volver) – Noticias Del Mundo En Español

) [summary] => Mundo Jurásico: Dominio es sin duda uno de los lanzamientos más esperados de este año. La tercera película en el Mundo franquicia y sexta película de franquicia en general se dirige a la calendario de cine 2022 el 10 de junio. Todavía faltan varias semanas, pero resulta que el elenco ya vio la película completa, ... Read more [atom_content] =>

Mundo Jurásico: Dominio es sin duda uno de los lanzamientos más esperados de este año. La tercera película en el Mundo franquicia y sexta película de franquicia en general se dirige a la calendario de cine 2022 el 10 de junio. Todavía faltan varias semanas, pero resulta que el elenco ya vio la película completa, y Jeff Goldblum y Bryce Dallas Howard aparecieron en CinemaCon este año para hablar sobre su «infinita gratitud» por la franquicia y compartir su primeras tomas de la película. Ah, y el estreno de la nueva película también será un momento dulce para la familia de Jeff Goldblum.

Antes de compartir algunas imágenes nuevas, Jeff Goldblum y Bryce Dallas Howard hablaron un poco sobre sus experiencias en la icónica franquicia. Para Goldblum, ir al cine siempre ha sido la experiencia más «romántica» y «mágica» para él y parece genuinamente entusiasmado con lo que Dominio está llevando a la gran pantalla.

We would like to say thanks to the author of this short article for this remarkable content

Jeff Goldblum Comparte Pensamientos Después De Ver Jurassic World: Dominion (y Ya Tiene Planes De Volver) – Noticias Del Mundo En Español

) [2] => Array ( [title] => Unravelling the origins of the human spine [link] => https://wikileaksisdemocracy.org/healthandscience/unravelling-the-origins-of-the-human-spine/ [dc] => Array ( [creator] => Tony Grantly ) [pubdate] => Fri, 29 Apr 2022 02:48:15 +0000 [category] => Health And SciencehumanoriginsspineUnravelling [guid] => https://wikileaksisdemocracy.org/?p=30147 [description] => Journal Reference: Marina Sanaki-Matsumiya, Mitsuhiro Matsuda, Nicola Gritti, Fumio Nakaki, James Sharpe, Vikas Trivedi, Miki Ebisuya. Periodic formation of epithelial somites from human pluripotent stem cells. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-29967-1 The spinal column consists of 33 vertebrae, which form pairs of precursor structures called somites. Somites give rise to not only our ... Read more [content] => Array ( [encoded] =>

Journal Reference:

  1. Marina Sanaki-Matsumiya, Mitsuhiro Matsuda, Nicola Gritti, Fumio Nakaki, James Sharpe, Vikas Trivedi, Miki Ebisuya. Periodic formation of epithelial somites from human pluripotent stem cells. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-29967-1

The spinal column consists of 33 vertebrae, which form pairs of precursor structures called somites. Somites give rise to not only our vertebrae, but also our ribs and skeletal muscles. To ensure that these structures are formed correctly, somite development is tightly regulated, and each pair of somites arises at a particular sequential time point in development. This process is controlled by the segmentation clock, which is a group of genes that creates oscillatory waves, every wave giving rise to a new pair of somites.

“For the first time, we have been able to create periodic pairs of human mature somites linked to the segmentation clock in the lab,” said Marina Sanaki-Matsumiya, first author of the study published in Nature Communications. Using this approach, the researchers developed a 3D in vitro model of human somite formation, also known as ‘somitogenesis’.

Creating a robust somitogenesis process

The team cultured human induced pluripotent stem cells (hiPSC) in the presence of a cocktail of signalling molecules that induce cell differentiation. Three days later, the cells started to elongate and create anterior (top) and posterior (bottom) axes. At that point, the scientists added Matrigel to the culture mix. Matrigel is what some scientists call the magic powder: a protein mixture that is critical to many developmental processes. This process eventually led to the formation of somitoids — in vitro equivalents of human somite precursor structures.

To test whether the segmentation clock regulates somitogenesis in these somitoids, the researchers monitored the expression patterns of HES7, the core gene involved in the process. They found clear evidence of oscillations, especially when somitogenesis was about to start. The somites that formed also had clear markers of epithelization — an important step in their maturation.

Somite size matters

The Ebisuya group studies how and why we humans are different from other species when it comes to embryonic development. One of the model systems they use to understand interspecies differences is the segmentation clock. In 2020, the group uncovered that the oscillation period of the human segmentation clock is longer than the mouse segmentation clock.

The current study also shows a link between the size of somites and the segmentation clock. “The somites that were generated had a constant size, independently of the number of cells used for the initial somitoid. The somite size did not increase even if the initial cell number did.” explained Sanaki-Matsumiya. “This suggests that the somites have a preferred species-specific size, which might be determined by local cell-cell interactions, the segmentation clock, or other mechanisms.”

To study this further, Miki Ebisuya and her group are now planning to grow somitoids of different species and compare them. The researchers are already working on several mammalian species, including rabbits, cattle, and rhinoceroses, setting up a ‘stem cell zoo’ in the lab.

“Our next project will focus on creating somitoids from different species, measure their cell proliferation and cell migration speed to establish what and how somitogenesis is different among species,” said Ebisuya.

We wish to give thanks to the author of this post for this outstanding web content

Unravelling the origins of the human spine

) [summary] => Journal Reference: Marina Sanaki-Matsumiya, Mitsuhiro Matsuda, Nicola Gritti, Fumio Nakaki, James Sharpe, Vikas Trivedi, Miki Ebisuya. Periodic formation of epithelial somites from human pluripotent stem cells. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-29967-1 The spinal column consists of 33 vertebrae, which form pairs of precursor structures called somites. Somites give rise to not only our ... Read more [atom_content] =>

Journal Reference:

  1. Marina Sanaki-Matsumiya, Mitsuhiro Matsuda, Nicola Gritti, Fumio Nakaki, James Sharpe, Vikas Trivedi, Miki Ebisuya. Periodic formation of epithelial somites from human pluripotent stem cells. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-29967-1

The spinal column consists of 33 vertebrae, which form pairs of precursor structures called somites. Somites give rise to not only our vertebrae, but also our ribs and skeletal muscles. To ensure that these structures are formed correctly, somite development is tightly regulated, and each pair of somites arises at a particular sequential time point in development. This process is controlled by the segmentation clock, which is a group of genes that creates oscillatory waves, every wave giving rise to a new pair of somites.

“For the first time, we have been able to create periodic pairs of human mature somites linked to the segmentation clock in the lab,” said Marina Sanaki-Matsumiya, first author of the study published in Nature Communications. Using this approach, the researchers developed a 3D in vitro model of human somite formation, also known as ‘somitogenesis’.

Creating a robust somitogenesis process

The team cultured human induced pluripotent stem cells (hiPSC) in the presence of a cocktail of signalling molecules that induce cell differentiation. Three days later, the cells started to elongate and create anterior (top) and posterior (bottom) axes. At that point, the scientists added Matrigel to the culture mix. Matrigel is what some scientists call the magic powder: a protein mixture that is critical to many developmental processes. This process eventually led to the formation of somitoids — in vitro equivalents of human somite precursor structures.

To test whether the segmentation clock regulates somitogenesis in these somitoids, the researchers monitored the expression patterns of HES7, the core gene involved in the process. They found clear evidence of oscillations, especially when somitogenesis was about to start. The somites that formed also had clear markers of epithelization — an important step in their maturation.

Somite size matters

The Ebisuya group studies how and why we humans are different from other species when it comes to embryonic development. One of the model systems they use to understand interspecies differences is the segmentation clock. In 2020, the group uncovered that the oscillation period of the human segmentation clock is longer than the mouse segmentation clock.

The current study also shows a link between the size of somites and the segmentation clock. “The somites that were generated had a constant size, independently of the number of cells used for the initial somitoid. The somite size did not increase even if the initial cell number did.” explained Sanaki-Matsumiya. “This suggests that the somites have a preferred species-specific size, which might be determined by local cell-cell interactions, the segmentation clock, or other mechanisms.”

To study this further, Miki Ebisuya and her group are now planning to grow somitoids of different species and compare them. The researchers are already working on several mammalian species, including rabbits, cattle, and rhinoceroses, setting up a ‘stem cell zoo’ in the lab.

“Our next project will focus on creating somitoids from different species, measure their cell proliferation and cell migration speed to establish what and how somitogenesis is different among species,” said Ebisuya.

We wish to give thanks to the author of this post for this outstanding web content

Unravelling the origins of the human spine

) [3] => Array ( [title] => Sampling the deep graveyard of Earth’s earliest crust [link] => https://wikileaksisdemocracy.org/healthandscience/sampling-the-deep-graveyard-of-earths-earliest-crust/ [dc] => Array ( [creator] => Tony Grantly ) [pubdate] => Fri, 29 Apr 2022 01:31:13 +0000 [category] => Health And SciencecrustDeepearliestEarthsgraveyardsampling [guid] => https://wikileaksisdemocracy.org/?p=30142 [description] => Journal Reference: Jonas Tusch, J. Elis Hoffmann, Eric Hasenstab, Mario Fischer-Gödde, Chris S. Marien, Allan H. Wilson, Carsten Münker. Long-term preservation of Hadean protocrust in Earth’s mantle. Proceedings of the National Academy of Sciences, 2022; 119 (18) DOI: 10.1073/pnas.2120241119 This finding is unexpected because the plate tectonic regime of our planet progressively recycles crustal material ... Read more [content] => Array ( [encoded] =>

Journal Reference:

  1. Jonas Tusch, J. Elis Hoffmann, Eric Hasenstab, Mario Fischer-Gödde, Chris S. Marien, Allan H. Wilson, Carsten Münker. Long-term preservation of Hadean protocrust in Earth’s mantle. Proceedings of the National Academy of Sciences, 2022; 119 (18) DOI: 10.1073/pnas.2120241119

This finding is unexpected because the plate tectonic regime of our planet progressively recycles crustal material via large-scale mantle convection at much smaller time scales. Therefore, it has been assumed that vestiges of early geological processes on Earth can only be found as analogues, on other terrestrial planets (Mercury, Venus, and Mars), asteroids, or the Moon. However, according to their study ‘Long-term preservation of Hadean protocrust in Earth’s mantle’, which has recently appeared in the Proceedings of the National Academy of Sciences (PNAS), magmatic rocks that erupted throughout Earth’s history can still carry signatures that provide detailed information about the nature of the first crust, its long-term preservation in a graveyard in the lower-most mantle, and its resurrection via younger volcanism.

For their study, the geologists investigated up to 3.55 billion years old rocks from southern Africa. The analysis of these rocks revealed small anomalies in the isotope composition of the element tungsten (W). The origin of these isotope anomalies, namely the relative abundance of 182W, relates to geological processes that must have occurred immediately after the formation of the Earth more than 4.5 billion years ago.

Model calculations by the authors show that the observed 182W isotope patterns are best explained by the recycling of Earth’s earliest crust into mantle material that ascends via plumes from the lower mantle to generate lavas erupting at Earth’s surface. Intriguingly, the study shows that similar isotope patterns can be observed in distinct types of modern volcanic rocks (ocean island basalts), which demonstrates that Earth’s earliest crust is still buried in the lowermost mantle.

‘We assume that the lower layers of the crust — or the roots of the primordial continents — became heavier than their surroundings due to a geological maturation process and therefore sank into the Earth’s underlying mantle. Similar to a lava lamp,’ geochemist Dr Jonas Tusch from the University of Cologne’s Institute of Geology and Mineralogy remarked. ‘This fascinating insight provides a geochemical fingerprint of the young Earth, allowing us to better understand how large continents formed over the history of our planet. It also explains how our current, oxygen-rich atmosphere evolved — setting the stage for the origin of complex life,’ Dr Elis Hoffmann of Freie Universität Berlin added.

The geochemical fingerprint of the early Earth can also be compared with findings about other planets obtained during space missions. For example, data from Mars missions and studies of Martian meteorites show that Mars still has a very old surface due to the lack of plate tectonics, and that its composition may correspond to that of the young Earth.

We want to give thanks to the writer of this article for this outstanding material

Sampling the deep graveyard of Earth’s earliest crust

) [summary] => Journal Reference: Jonas Tusch, J. Elis Hoffmann, Eric Hasenstab, Mario Fischer-Gödde, Chris S. Marien, Allan H. Wilson, Carsten Münker. Long-term preservation of Hadean protocrust in Earth’s mantle. Proceedings of the National Academy of Sciences, 2022; 119 (18) DOI: 10.1073/pnas.2120241119 This finding is unexpected because the plate tectonic regime of our planet progressively recycles crustal material ... Read more [atom_content] =>

Journal Reference:

  1. Jonas Tusch, J. Elis Hoffmann, Eric Hasenstab, Mario Fischer-Gödde, Chris S. Marien, Allan H. Wilson, Carsten Münker. Long-term preservation of Hadean protocrust in Earth’s mantle. Proceedings of the National Academy of Sciences, 2022; 119 (18) DOI: 10.1073/pnas.2120241119

This finding is unexpected because the plate tectonic regime of our planet progressively recycles crustal material via large-scale mantle convection at much smaller time scales. Therefore, it has been assumed that vestiges of early geological processes on Earth can only be found as analogues, on other terrestrial planets (Mercury, Venus, and Mars), asteroids, or the Moon. However, according to their study ‘Long-term preservation of Hadean protocrust in Earth’s mantle’, which has recently appeared in the Proceedings of the National Academy of Sciences (PNAS), magmatic rocks that erupted throughout Earth’s history can still carry signatures that provide detailed information about the nature of the first crust, its long-term preservation in a graveyard in the lower-most mantle, and its resurrection via younger volcanism.

For their study, the geologists investigated up to 3.55 billion years old rocks from southern Africa. The analysis of these rocks revealed small anomalies in the isotope composition of the element tungsten (W). The origin of these isotope anomalies, namely the relative abundance of 182W, relates to geological processes that must have occurred immediately after the formation of the Earth more than 4.5 billion years ago.

Model calculations by the authors show that the observed 182W isotope patterns are best explained by the recycling of Earth’s earliest crust into mantle material that ascends via plumes from the lower mantle to generate lavas erupting at Earth’s surface. Intriguingly, the study shows that similar isotope patterns can be observed in distinct types of modern volcanic rocks (ocean island basalts), which demonstrates that Earth’s earliest crust is still buried in the lowermost mantle.

‘We assume that the lower layers of the crust — or the roots of the primordial continents — became heavier than their surroundings due to a geological maturation process and therefore sank into the Earth’s underlying mantle. Similar to a lava lamp,’ geochemist Dr Jonas Tusch from the University of Cologne’s Institute of Geology and Mineralogy remarked. ‘This fascinating insight provides a geochemical fingerprint of the young Earth, allowing us to better understand how large continents formed over the history of our planet. It also explains how our current, oxygen-rich atmosphere evolved — setting the stage for the origin of complex life,’ Dr Elis Hoffmann of Freie Universität Berlin added.

The geochemical fingerprint of the early Earth can also be compared with findings about other planets obtained during space missions. For example, data from Mars missions and studies of Martian meteorites show that Mars still has a very old surface due to the lack of plate tectonics, and that its composition may correspond to that of the young Earth.

We want to give thanks to the writer of this article for this outstanding material

Sampling the deep graveyard of Earth’s earliest crust

) [4] => Array ( [title] => Engineers get under the skin of ionic skin [link] => https://wikileaksisdemocracy.org/healthandscience/engineers-get-under-the-skin-of-ionic-skin/ [dc] => Array ( [creator] => Tony Grantly ) [pubdate] => Fri, 29 Apr 2022 00:14:10 +0000 [category] => Health And ScienceEngineersIonicskin [guid] => https://wikileaksisdemocracy.org/?p=30137 [description] => Journal Reference: Yuta Dobashi, Dickson Yao, Yael Petel, Tan Ngoc Nguyen, Mirza Saquib Sarwar, Yacine Thabet, Cliff L. W. Ng, Ettore Scabeni Glitz, Giao Tran Minh Nguyen, Cédric Plesse, Frédéric Vidal, Carl A. Michal, John D. W. Madden. Piezoionic mechanoreceptors: Force-induced current generation in hydrogels. Science, 2022; 376 (6592): 502 DOI: 10.1126/science.aaw1974 These hydrogels can ... Read more [content] => Array ( [encoded] =>

Journal Reference:

  1. Yuta Dobashi, Dickson Yao, Yael Petel, Tan Ngoc Nguyen, Mirza Saquib Sarwar, Yacine Thabet, Cliff L. W. Ng, Ettore Scabeni Glitz, Giao Tran Minh Nguyen, Cédric Plesse, Frédéric Vidal, Carl A. Michal, John D. W. Madden. Piezoionic mechanoreceptors: Force-induced current generation in hydrogels. Science, 2022; 376 (6592): 502 DOI: 10.1126/science.aaw1974

These hydrogels can generate voltages when touched, but scientists did not clearly understand how — until a team of researchers at UBC devised a unique experiment, published today in Science.

“How hydrogel sensors work is they produce voltages and currents in reaction to stimuli, such as pressure or touch — what we are calling a piezoionic effect. But we didn’t know exactly how these voltages are produced,” said the study’s lead author Yuta Dobashi, who started the work as part of his master’s in biomedical engineering at UBC.

Working under the supervision of UBC researcher Dr. John Madden, Dobashi devised hydrogel sensors containing salts with positive and negative ions of different sizes. He and collaborators in UBC’s physics and chemistry departments applied magnetic fields to track precisely how the ions moved when pressure was applied to the sensor.

“When pressure is applied to the gel, that pressure spreads out the ions in the liquid at different speeds, creating an electrical signal. Positive ions, which tend to be smaller, move faster than larger, negative ions. This results in an uneven ion distribution which creates an electric field, which is what makes a piezoionic sensor work.”

The researchers say this new knowledge confirms that hydrogels work in a similar way to how humans detect pressure, which is also through moving ions in response to pressure, inspiring potential new applications for ionic skins.

“The obvious application is creating sensors that interact directly with cells and the nervous system, since the voltages, currents and response times are like those across cell membranes,” says Dr. Madden, an electrical and computer engineering professor in UBC’s faculty of applied science. “When we connect our sensor to a nerve, it produces a signal in the nerve. The nerve, in turn, activates muscle contraction.”

“You can imagine a prosthetic arm covered in an ionic skin. The skin senses an object through touch or pressure, conveys that information through the nerves to the brain, and the brain then activates the motors required to lift or hold the object. With further development of the sensor skin and interfaces with nerves, this bionic interface is conceivable.”

Another application is a soft hydrogel sensor worn on the skin that can monitor a patient’s vital signs while being totally unobtrusive and generating its own power.

Dobashi, who’s currently completing his PhD work at the University of Toronto, is keen to continue working on ionic technologies after he graduates.

“We can imagine a future where jelly-like ‘iontronics’ are used for body implants. Artificial joints can be implanted, without fear of rejection inside the human body. Ionic devices can be used as part of artificial knee cartilage, adding a smart sensing element. A piezoionic gel implant might release drugs based on how much pressure it senses, for example.”

Dr. Madden added that the market for smart skins is estimated at $4.5 billion in 2019 and it continues to grow. “Smart skins can be integrated into clothing or placed directly on the skin, and ionic skins are one of the technologies that can further that growth.”

The research includes contributions from UBC chemistry PhD graduate Yael Petel and Carl Michal, UBC professor of physics, who used the interaction between strong magnetic fields and the nuclear spins of ions to track ion movements within the hydrogels. Cédric Plesse, Giao Nguyen and Frédéric Vidal at CY Cergy Paris University in France helped develop a new theory on how the charge and voltage are generated in the hydrogels.

We want to give thanks to the writer of this short article for this amazing content

Engineers get under the skin of ionic skin

) [summary] => Journal Reference: Yuta Dobashi, Dickson Yao, Yael Petel, Tan Ngoc Nguyen, Mirza Saquib Sarwar, Yacine Thabet, Cliff L. W. Ng, Ettore Scabeni Glitz, Giao Tran Minh Nguyen, Cédric Plesse, Frédéric Vidal, Carl A. Michal, John D. W. Madden. Piezoionic mechanoreceptors: Force-induced current generation in hydrogels. Science, 2022; 376 (6592): 502 DOI: 10.1126/science.aaw1974 These hydrogels can ... Read more [atom_content] =>

Journal Reference:

  1. Yuta Dobashi, Dickson Yao, Yael Petel, Tan Ngoc Nguyen, Mirza Saquib Sarwar, Yacine Thabet, Cliff L. W. Ng, Ettore Scabeni Glitz, Giao Tran Minh Nguyen, Cédric Plesse, Frédéric Vidal, Carl A. Michal, John D. W. Madden. Piezoionic mechanoreceptors: Force-induced current generation in hydrogels. Science, 2022; 376 (6592): 502 DOI: 10.1126/science.aaw1974

These hydrogels can generate voltages when touched, but scientists did not clearly understand how — until a team of researchers at UBC devised a unique experiment, published today in Science.

“How hydrogel sensors work is they produce voltages and currents in reaction to stimuli, such as pressure or touch — what we are calling a piezoionic effect. But we didn’t know exactly how these voltages are produced,” said the study’s lead author Yuta Dobashi, who started the work as part of his master’s in biomedical engineering at UBC.

Working under the supervision of UBC researcher Dr. John Madden, Dobashi devised hydrogel sensors containing salts with positive and negative ions of different sizes. He and collaborators in UBC’s physics and chemistry departments applied magnetic fields to track precisely how the ions moved when pressure was applied to the sensor.

“When pressure is applied to the gel, that pressure spreads out the ions in the liquid at different speeds, creating an electrical signal. Positive ions, which tend to be smaller, move faster than larger, negative ions. This results in an uneven ion distribution which creates an electric field, which is what makes a piezoionic sensor work.”

The researchers say this new knowledge confirms that hydrogels work in a similar way to how humans detect pressure, which is also through moving ions in response to pressure, inspiring potential new applications for ionic skins.

“The obvious application is creating sensors that interact directly with cells and the nervous system, since the voltages, currents and response times are like those across cell membranes,” says Dr. Madden, an electrical and computer engineering professor in UBC’s faculty of applied science. “When we connect our sensor to a nerve, it produces a signal in the nerve. The nerve, in turn, activates muscle contraction.”

“You can imagine a prosthetic arm covered in an ionic skin. The skin senses an object through touch or pressure, conveys that information through the nerves to the brain, and the brain then activates the motors required to lift or hold the object. With further development of the sensor skin and interfaces with nerves, this bionic interface is conceivable.”

Another application is a soft hydrogel sensor worn on the skin that can monitor a patient’s vital signs while being totally unobtrusive and generating its own power.

Dobashi, who’s currently completing his PhD work at the University of Toronto, is keen to continue working on ionic technologies after he graduates.

“We can imagine a future where jelly-like ‘iontronics’ are used for body implants. Artificial joints can be implanted, without fear of rejection inside the human body. Ionic devices can be used as part of artificial knee cartilage, adding a smart sensing element. A piezoionic gel implant might release drugs based on how much pressure it senses, for example.”

Dr. Madden added that the market for smart skins is estimated at $4.5 billion in 2019 and it continues to grow. “Smart skins can be integrated into clothing or placed directly on the skin, and ionic skins are one of the technologies that can further that growth.”

The research includes contributions from UBC chemistry PhD graduate Yael Petel and Carl Michal, UBC professor of physics, who used the interaction between strong magnetic fields and the nuclear spins of ions to track ion movements within the hydrogels. Cédric Plesse, Giao Nguyen and Frédéric Vidal at CY Cergy Paris University in France helped develop a new theory on how the charge and voltage are generated in the hydrogels.

We want to give thanks to the writer of this short article for this amazing content

Engineers get under the skin of ionic skin

) [5] => Array ( [title] => Ucraina, diretta. Missili su Kiev durante la visita di Guterres. Usa: truppe russe lasciano Mariupol [link] => https://wikileaksisdemocracy.org/sport/ucraina-diretta-missili-su-kiev-durante-la-visita-di-guterres-usa-truppe-russe-lasciano-mariupol/ [dc] => Array ( [creator] => Tim Hall ) [pubdate] => Fri, 29 Apr 2022 00:06:15 +0000 [category] => SportdirettaduranteGuterresKIevlascianoMariupolMissilirussetruppeUcrainaUSAvisita [guid] => https://wikileaksisdemocracy.org/?p=30131 [description] => Due forti esplosioni colpiscono Kiev proprio mentre il segretario generale dell’Onu, Antonio Guterres, sta tracciando il bilancio degli incontri avuti con il presidente russo Vladimir Putin e con quello ucraino Volodymyr Zelensky. «L’attacco alla Capitale mi ha sconvolto», dice mentre una nuvola di fumo nero si intravede in lontananza. Guterres parla alla stampa insieme con ... Read more [content] => Array ( [encoded] =>

Due forti esplosioni colpiscono Kiev proprio mentre il segretario generale dell’Onu, Antonio Guterres, sta tracciando il bilancio degli incontri avuti con il presidente russo Vladimir Putin e con quello ucraino Volodymyr Zelensky. «L’attacco alla Capitale mi ha sconvolto», dice mentre una nuvola di fumo nero si intravede in lontananza. Guterres parla alla stampa insieme con il presidente ucraino Volodymyr Zelensky e le sue parole non sono affatto confortanti: il Consiglio di sicurezza dell’Onu «non è riuscito a prevenire e a porre fine» alla guerra. Le Nazioni Unite hanno fallito nel conflitto ucraino. «Possiamo avere tutte le riunioni, ma non è questo che farà finire la guerra – spiega -. Putin concorda in linea di principio sulla necessità» di evacuare i civili verso i territori sotto controllo di Kiev, in particolare riguardo ai civili bloccati nell’acciaieria Azovstal di Mariupol, anche se «la guerra finirà quando vincerà Mosca». 

L’EVACUAZIONE

Salvare i resistenti dell’impianto nella città martire, è questa la parola d’ordine. Sono in corso discussioni tra funzionari Onu e il ministero della Difesa russo proprio per mettere a punto i dettagli, e Guterres chiarisce che ci sono contatti con il governo di Kiev, «per trovare una soluzione». Zelensky chiede «all’Onu di fare passi per impedire la deportazione degli ucraini in Russia. Speriamo – afferma – che con la mediazione di Guterres sia più concreta la possibilità che civili e militari vengano evacuati da Mariupol».

I bombardamenti inaspettati sulla Capitale mentre il rappresentante dell’Onu è in città vengono denunciati con un tweet dal ministro degli esteri ucraino Dmytro Kuleba. «La Russia – scrive – ha colpito Kiev con missili da crociera proprio quando il segretario generale delle Nazioni Unite e il premier bulgaro Kiril Petkov sono in visita nella nostra capitale. Con questo atroce atto di barbarie dimostra ancora una volta il suo atteggiamento nei confronti dell’Ucraina, dell’Europa e del mondo». Il bilancio del bombardamento è di un paio di vittime: le truppe dello zar hanno colpito un palazzo residenziale, ma soprattutto hanno scelto una zona molto vicina all’ambasciata britannica. Durissimo Zelensky: «Cinque missili. Questo la dice lunga sul vero atteggiamento della Russia nei confronti delle istituzioni globali, sugli sforzi della leadership russa per umiliare le Nazioni Unite e tutto il resto che l’organizzazione rappresenta. E quindi serve una risposta appropriata e potente».
La guerra, dunque, continua a combattersi su più fronti. Ma se le truppe del Cremlino lanciano continui segnali contro la Capitale, la vera offensiva è nell’Ucraina orientale e meridionale. La Russia accelera. «Il nemico – conferma il Comando militare ucraino – sta aumentando il numero di attacchi e colpisce in ogni direzione». Forti esplosioni sono state sentite anche a Odessa. E per i funzionari di Kiev, il fulcro dell’attacco principale è stato vicino alle città di Slobozhanske e Donetsk, lungo un’autostrada strategica che collegava la seconda città più grande dell’Ucraina, Kharkiv, con la città occupata dai russi di Izyum. Il governatore regionale di Kharkiv afferma che, nonostante gli attacchi di Mosca si stiano intensificando, le truppe ucraine stanno mantenendo la loro posizione. 

In queste ore, poi, secondo la ricostruzione di un alto funzionario della Difesa americana, un numero imprecisato di forze russe si sta spostando da Mariupol – dove è stato colpito l’ospedale di campo militare all’interno dell’acciaieria con morti e feriti -, anche verso Nord-Ovest, sebbene i combattimenti nella città portuale ucraina continuino. E sembrano avere la meglio i soldati di Mosca anche sul fronte del Donbass. I progressi sono «lenti e irregolari», in parte a causa della resistenza ucraina, in parte per via dei continui problemi logistici. Ma, secondo fonti della Difesa americana, le truppe di Putin stanno avanzando. Sarà una guerra lunga – spiegano – Durerà ancora molto tempo. Le autorità locali ucraine denunciano che gli occupanti russi puntano ad istituzionalizzare la loro presenza nei territori conquistati. A Kherson (Sud) è stato annunciato che la regione passerà all’uso del rublo, la moneta russa, dal primo maggio, con un periodo di transizione di quattro mesi durante il quale sarà ammessa anche la grivnia ucraina. A Mariupol, invece, sostengono che l’autoproclamato sindaco filorusso della città ha detto che questa entrerà a far parte della regione russa di Rostov. E prosegue lo scambio di accuse di atrocità fra Mosca e Washington: gli Usa denunciano di aver ricevuto «informazioni credibili» su «esecuzioni di persone alle quali erano state legate le mani, torture e violenze sessuali contro donne e ragazze» a Donetsk. E come sempre sta accadendo in questa guerra, Mosca replica parlando della scoperta di un «centro di tortura ucraino» a Mariupol. 

Prima del suo incontro con il presidente Zelensky, Guterres ha visitato vari centri nella regione di Kiev dove, dopo il ritiro dei russi, gli ucraini hanno denunciato atrocità da parte delle truppe di occupazione. «Quando vedo questi palazzi distrutti dalla guerra, immagino la mia famiglia, mia nipote nel panico e in fuga. Questa distruzione è inaccettabile nel XXI secolo», dichiara mentre sosta nella via principale di Borodianka, davanti a cinque palazzi di 10 piani parzialmente crollati e bruciati.

IL BUNDESTAG 

E intanto il Bundestag – con voti di maggioranza ed opposizione – ha approvato la consegna di armi pesanti a Kiev, mentre il ministro di Difesa britannico Ben Wallace ha assicurato che a breve il Regno Unito fornirà non solo missili a lungo raggio Brimstone, usati come armi terra-terra, ma anche specifiche batterie «anti nave». Wallace ha respinto le accuse russe di un coinvolgimento della Nato nel conflitto, sostenendo che Londra fornisce armi «come 40 altri Paesi in base ad accordi bilaterali». Ma il portavoce del Cremlino insiste: l’invio di armi in Ucraina costituisce «una minaccia per la sicurezza dell’Europa», e la Cina denuncia che la Nato è «uno strumento di singoli Paesi per cercare l’egemonia» non solo nel Nord Atlantico, ma anche nell’Asia-Pacifico, verso cui si è rivolta negli ultimi anni «per mostrare la sua potenza e fomentare conflitti».
La Germania con la consegna di armi non intende, comunque, diventare parte in guerra ma non può lasciare l’Ucraina indifesa all’aggressione russa e per questo il Bundestag ha dato mandato al Governo di «continuare nella consegna di attrezzature idonee all’Ucraina, e dove possibile anche accelerarla, e tra queste l’invio di armi pesanti e sistemi complessi, allargando accordi di triangolazione», senza tuttavia pregiudicare le capacità di difesa tedesca nell’alleanza Nato, ampliando la partecipazione alla difesa del fianco orientale, specie dei Paesi Baltici, anche con altri soldati e mezzi. Il fine è il mantenimento dell’ordine di pace e sicurezza in Europa in cui a tutti gli Stati è garantita l’intangibilità delle frontiere.

Anche in Italia, ieri, è stato dato il via libera alla seconda tranche di armi all’Ucraina. Il decreto – siglato dal ministro della Difesa, Guerini, insieme a Di Maio (Esteri) e a Franco (Economia) – è stato pubblicato in Gazzetta Ufficiale. Secretata la lista, ma Guerini ha riferito in proposito al Copasir in un’audizione durata circa due ore. Si tratta, ha spiegato il ministro, di materiale bellico della stessa natura di quello inviato con il primo decreto: missili anti-aereo Stinger, missili anti-carro Milan, mortai da 120 mm, mitragliatrici pesanti e leggere, giubbotti antiproiettile, elmetti, razioni k, proiettili e munizionamenti in grande quantità. Due mesi di guerra hanno messo a dura prova le dotazioni del Paese aggredito: è dunque necessario un ricambio. Un possibile salto di qualità del materiale da trasferire – a esempio, mezzi pesanti come i semoventi d’artiglieria M109, i cingolati M113 e i più leggeri blindati Lince – verrà valutato successivamente e sarà eventualmente oggetto di un ulteriore decreto interministeriale. 

LA DIFESA

C’è una ricognizione in atto da parte dello Stato Maggiore della Difesa, ma ci sono anche valutazioni politiche in capo al premier Mario Draghi dopo la levata di scudi del leader M5s Giuseppe Conte. E dagli Stati Uniti il presidente americano Joe Biden ha ribadito: «Finché continueranno gli assalti e le atrocità, continueremo ad aiutare l’Ucraina a difendersi dall’aggressione russa, inviando altre armi e nuovi aiuti». 

© RIPRODUZIONE RISERVATA

We want to give thanks to the author of this write-up for this amazing web content

Ucraina, diretta. Missili su Kiev durante la visita di Guterres. Usa: truppe russe lasciano Mariupol

) [summary] => Due forti esplosioni colpiscono Kiev proprio mentre il segretario generale dell’Onu, Antonio Guterres, sta tracciando il bilancio degli incontri avuti con il presidente russo Vladimir Putin e con quello ucraino Volodymyr Zelensky. «L’attacco alla Capitale mi ha sconvolto», dice mentre una nuvola di fumo nero si intravede in lontananza. Guterres parla alla stampa insieme con ... Read more [atom_content] =>

Due forti esplosioni colpiscono Kiev proprio mentre il segretario generale dell’Onu, Antonio Guterres, sta tracciando il bilancio degli incontri avuti con il presidente russo Vladimir Putin e con quello ucraino Volodymyr Zelensky. «L’attacco alla Capitale mi ha sconvolto», dice mentre una nuvola di fumo nero si intravede in lontananza. Guterres parla alla stampa insieme con il presidente ucraino Volodymyr Zelensky e le sue parole non sono affatto confortanti: il Consiglio di sicurezza dell’Onu «non è riuscito a prevenire e a porre fine» alla guerra. Le Nazioni Unite hanno fallito nel conflitto ucraino. «Possiamo avere tutte le riunioni, ma non è questo che farà finire la guerra – spiega -. Putin concorda in linea di principio sulla necessità» di evacuare i civili verso i territori sotto controllo di Kiev, in particolare riguardo ai civili bloccati nell’acciaieria Azovstal di Mariupol, anche se «la guerra finirà quando vincerà Mosca». 

L’EVACUAZIONE

Salvare i resistenti dell’impianto nella città martire, è questa la parola d’ordine. Sono in corso discussioni tra funzionari Onu e il ministero della Difesa russo proprio per mettere a punto i dettagli, e Guterres chiarisce che ci sono contatti con il governo di Kiev, «per trovare una soluzione». Zelensky chiede «all’Onu di fare passi per impedire la deportazione degli ucraini in Russia. Speriamo – afferma – che con la mediazione di Guterres sia più concreta la possibilità che civili e militari vengano evacuati da Mariupol».

I bombardamenti inaspettati sulla Capitale mentre il rappresentante dell’Onu è in città vengono denunciati con un tweet dal ministro degli esteri ucraino Dmytro Kuleba. «La Russia – scrive – ha colpito Kiev con missili da crociera proprio quando il segretario generale delle Nazioni Unite e il premier bulgaro Kiril Petkov sono in visita nella nostra capitale. Con questo atroce atto di barbarie dimostra ancora una volta il suo atteggiamento nei confronti dell’Ucraina, dell’Europa e del mondo». Il bilancio del bombardamento è di un paio di vittime: le truppe dello zar hanno colpito un palazzo residenziale, ma soprattutto hanno scelto una zona molto vicina all’ambasciata britannica. Durissimo Zelensky: «Cinque missili. Questo la dice lunga sul vero atteggiamento della Russia nei confronti delle istituzioni globali, sugli sforzi della leadership russa per umiliare le Nazioni Unite e tutto il resto che l’organizzazione rappresenta. E quindi serve una risposta appropriata e potente».
La guerra, dunque, continua a combattersi su più fronti. Ma se le truppe del Cremlino lanciano continui segnali contro la Capitale, la vera offensiva è nell’Ucraina orientale e meridionale. La Russia accelera. «Il nemico – conferma il Comando militare ucraino – sta aumentando il numero di attacchi e colpisce in ogni direzione». Forti esplosioni sono state sentite anche a Odessa. E per i funzionari di Kiev, il fulcro dell’attacco principale è stato vicino alle città di Slobozhanske e Donetsk, lungo un’autostrada strategica che collegava la seconda città più grande dell’Ucraina, Kharkiv, con la città occupata dai russi di Izyum. Il governatore regionale di Kharkiv afferma che, nonostante gli attacchi di Mosca si stiano intensificando, le truppe ucraine stanno mantenendo la loro posizione. 

In queste ore, poi, secondo la ricostruzione di un alto funzionario della Difesa americana, un numero imprecisato di forze russe si sta spostando da Mariupol – dove è stato colpito l’ospedale di campo militare all’interno dell’acciaieria con morti e feriti -, anche verso Nord-Ovest, sebbene i combattimenti nella città portuale ucraina continuino. E sembrano avere la meglio i soldati di Mosca anche sul fronte del Donbass. I progressi sono «lenti e irregolari», in parte a causa della resistenza ucraina, in parte per via dei continui problemi logistici. Ma, secondo fonti della Difesa americana, le truppe di Putin stanno avanzando. Sarà una guerra lunga – spiegano – Durerà ancora molto tempo. Le autorità locali ucraine denunciano che gli occupanti russi puntano ad istituzionalizzare la loro presenza nei territori conquistati. A Kherson (Sud) è stato annunciato che la regione passerà all’uso del rublo, la moneta russa, dal primo maggio, con un periodo di transizione di quattro mesi durante il quale sarà ammessa anche la grivnia ucraina. A Mariupol, invece, sostengono che l’autoproclamato sindaco filorusso della città ha detto che questa entrerà a far parte della regione russa di Rostov. E prosegue lo scambio di accuse di atrocità fra Mosca e Washington: gli Usa denunciano di aver ricevuto «informazioni credibili» su «esecuzioni di persone alle quali erano state legate le mani, torture e violenze sessuali contro donne e ragazze» a Donetsk. E come sempre sta accadendo in questa guerra, Mosca replica parlando della scoperta di un «centro di tortura ucraino» a Mariupol. 

Prima del suo incontro con il presidente Zelensky, Guterres ha visitato vari centri nella regione di Kiev dove, dopo il ritiro dei russi, gli ucraini hanno denunciato atrocità da parte delle truppe di occupazione. «Quando vedo questi palazzi distrutti dalla guerra, immagino la mia famiglia, mia nipote nel panico e in fuga. Questa distruzione è inaccettabile nel XXI secolo», dichiara mentre sosta nella via principale di Borodianka, davanti a cinque palazzi di 10 piani parzialmente crollati e bruciati.

IL BUNDESTAG 

E intanto il Bundestag – con voti di maggioranza ed opposizione – ha approvato la consegna di armi pesanti a Kiev, mentre il ministro di Difesa britannico Ben Wallace ha assicurato che a breve il Regno Unito fornirà non solo missili a lungo raggio Brimstone, usati come armi terra-terra, ma anche specifiche batterie «anti nave». Wallace ha respinto le accuse russe di un coinvolgimento della Nato nel conflitto, sostenendo che Londra fornisce armi «come 40 altri Paesi in base ad accordi bilaterali». Ma il portavoce del Cremlino insiste: l’invio di armi in Ucraina costituisce «una minaccia per la sicurezza dell’Europa», e la Cina denuncia che la Nato è «uno strumento di singoli Paesi per cercare l’egemonia» non solo nel Nord Atlantico, ma anche nell’Asia-Pacifico, verso cui si è rivolta negli ultimi anni «per mostrare la sua potenza e fomentare conflitti».
La Germania con la consegna di armi non intende, comunque, diventare parte in guerra ma non può lasciare l’Ucraina indifesa all’aggressione russa e per questo il Bundestag ha dato mandato al Governo di «continuare nella consegna di attrezzature idonee all’Ucraina, e dove possibile anche accelerarla, e tra queste l’invio di armi pesanti e sistemi complessi, allargando accordi di triangolazione», senza tuttavia pregiudicare le capacità di difesa tedesca nell’alleanza Nato, ampliando la partecipazione alla difesa del fianco orientale, specie dei Paesi Baltici, anche con altri soldati e mezzi. Il fine è il mantenimento dell’ordine di pace e sicurezza in Europa in cui a tutti gli Stati è garantita l’intangibilità delle frontiere.

Anche in Italia, ieri, è stato dato il via libera alla seconda tranche di armi all’Ucraina. Il decreto – siglato dal ministro della Difesa, Guerini, insieme a Di Maio (Esteri) e a Franco (Economia) – è stato pubblicato in Gazzetta Ufficiale. Secretata la lista, ma Guerini ha riferito in proposito al Copasir in un’audizione durata circa due ore. Si tratta, ha spiegato il ministro, di materiale bellico della stessa natura di quello inviato con il primo decreto: missili anti-aereo Stinger, missili anti-carro Milan, mortai da 120 mm, mitragliatrici pesanti e leggere, giubbotti antiproiettile, elmetti, razioni k, proiettili e munizionamenti in grande quantità. Due mesi di guerra hanno messo a dura prova le dotazioni del Paese aggredito: è dunque necessario un ricambio. Un possibile salto di qualità del materiale da trasferire – a esempio, mezzi pesanti come i semoventi d’artiglieria M109, i cingolati M113 e i più leggeri blindati Lince – verrà valutato successivamente e sarà eventualmente oggetto di un ulteriore decreto interministeriale. 

LA DIFESA

C’è una ricognizione in atto da parte dello Stato Maggiore della Difesa, ma ci sono anche valutazioni politiche in capo al premier Mario Draghi dopo la levata di scudi del leader M5s Giuseppe Conte. E dagli Stati Uniti il presidente americano Joe Biden ha ribadito: «Finché continueranno gli assalti e le atrocità, continueremo ad aiutare l’Ucraina a difendersi dall’aggressione russa, inviando altre armi e nuovi aiuti». 

© RIPRODUZIONE RISERVATA

We want to give thanks to the author of this write-up for this amazing web content

Ucraina, diretta. Missili su Kiev durante la visita di Guterres. Usa: truppe russe lasciano Mariupol

) [6] => Array ( [title] => Neuronal plasticity in chronic pain-induced anxiety revealed [link] => https://wikileaksisdemocracy.org/healthandscience/neuronal-plasticity-in-chronic-pain-induced-anxiety-revealed/ [dc] => Array ( [creator] => Tony Grantly ) [pubdate] => Thu, 28 Apr 2022 22:57:06 +0000 [category] => Health And Scienceanxietychronicneuronalpaininducedplasticityrevealed [guid] => https://wikileaksisdemocracy.org/?p=30126 [description] => Journal Reference: Naoki Yamauchi, Keiichiro Sato, Kenta Sato, Shunsaku Murakawa, Yumi Hamasaki, Hiroshi Nomura, Taiju Amano, Masabumi Minami. Chronic pain–induced neuronal plasticity in the bed nucleus of the stria terminalis causes maladaptive anxiety. Science Advances, 2022; 8 (17) DOI: 10.1126/sciadv.abj5586 Chronic pain is persistent and inescapable, and can lead to maladaptive emotional states. It is ... Read more [content] => Array ( [encoded] =>

Journal Reference:

  1. Naoki Yamauchi, Keiichiro Sato, Kenta Sato, Shunsaku Murakawa, Yumi Hamasaki, Hiroshi Nomura, Taiju Amano, Masabumi Minami. Chronic pain–induced neuronal plasticity in the bed nucleus of the stria terminalis causes maladaptive anxiety. Science Advances, 2022; 8 (17) DOI: 10.1126/sciadv.abj5586

Chronic pain is persistent and inescapable, and can lead to maladaptive emotional states. It is often comorbid with psychiatric disorders, such as depression and anxiety disorders. It is thought that chronic pain causes changes in neural circuits, and gives rise to depression and anxiety.

Researchers at Hokkaido University have identified the neuronal circuit involved in chronic pain-induced anxiety in mice. Their research, which was recently published in Science Advances, could lead to the development of new treatments for chronic pain and psychiatric disorders such as anxiety disorders and major depressive disorder.

“Clinicians have known for a long time that chronic pain often leads to anxiety and depression, however the brain mechanism for this was unclear,” said Professor Masabumi Minami of the Faculty of Pharmaceutical Sciences at Hokkaido University, the corresponding author of the paper.

The researchers looked at how neuronal circuits were affected by chronic pain in mice. They used an electrophysiological technique to measure the activities of neurons after four weeks of chronic pain. They found that chronic pain caused the neuroplastic change which suppressed the neuronal pathway projecting from the brain region called bed nucleus of the stria terminalis (BNST) to the region called lateral hypothalamus (LH).

Using chemogenetics, an advanced technique to manipulate neuronal activity, they showed that restoration of the suppressed activity of this neuronal pathway attenuated the chronic pain-induced anxiety. These findings indicate that chronic pain-induced functional changes in the neuronal circuits within the BNST leads to maladaptive anxiety.

“These findings could not only lead to improved treatment of chronic pain, but also to new therapeutics for anxiety disorders,” says Minami.

We would love to give thanks to the writer of this post for this outstanding web content

Neuronal plasticity in chronic pain-induced anxiety revealed

) [summary] => Journal Reference: Naoki Yamauchi, Keiichiro Sato, Kenta Sato, Shunsaku Murakawa, Yumi Hamasaki, Hiroshi Nomura, Taiju Amano, Masabumi Minami. Chronic pain–induced neuronal plasticity in the bed nucleus of the stria terminalis causes maladaptive anxiety. Science Advances, 2022; 8 (17) DOI: 10.1126/sciadv.abj5586 Chronic pain is persistent and inescapable, and can lead to maladaptive emotional states. It is ... Read more [atom_content] =>

Journal Reference:

  1. Naoki Yamauchi, Keiichiro Sato, Kenta Sato, Shunsaku Murakawa, Yumi Hamasaki, Hiroshi Nomura, Taiju Amano, Masabumi Minami. Chronic pain–induced neuronal plasticity in the bed nucleus of the stria terminalis causes maladaptive anxiety. Science Advances, 2022; 8 (17) DOI: 10.1126/sciadv.abj5586

Chronic pain is persistent and inescapable, and can lead to maladaptive emotional states. It is often comorbid with psychiatric disorders, such as depression and anxiety disorders. It is thought that chronic pain causes changes in neural circuits, and gives rise to depression and anxiety.

Researchers at Hokkaido University have identified the neuronal circuit involved in chronic pain-induced anxiety in mice. Their research, which was recently published in Science Advances, could lead to the development of new treatments for chronic pain and psychiatric disorders such as anxiety disorders and major depressive disorder.

“Clinicians have known for a long time that chronic pain often leads to anxiety and depression, however the brain mechanism for this was unclear,” said Professor Masabumi Minami of the Faculty of Pharmaceutical Sciences at Hokkaido University, the corresponding author of the paper.

The researchers looked at how neuronal circuits were affected by chronic pain in mice. They used an electrophysiological technique to measure the activities of neurons after four weeks of chronic pain. They found that chronic pain caused the neuroplastic change which suppressed the neuronal pathway projecting from the brain region called bed nucleus of the stria terminalis (BNST) to the region called lateral hypothalamus (LH).

Using chemogenetics, an advanced technique to manipulate neuronal activity, they showed that restoration of the suppressed activity of this neuronal pathway attenuated the chronic pain-induced anxiety. These findings indicate that chronic pain-induced functional changes in the neuronal circuits within the BNST leads to maladaptive anxiety.

“These findings could not only lead to improved treatment of chronic pain, but also to new therapeutics for anxiety disorders,” says Minami.

We would love to give thanks to the writer of this post for this outstanding web content

Neuronal plasticity in chronic pain-induced anxiety revealed

) [7] => Array ( [title] => Et si nous étions plus utiles que nous ne l’imaginons ? [link] => https://wikileaksisdemocracy.org/lifestyle/et-si-nous-etions-plus-utiles-que-nous-ne-limaginons/ [dc] => Array ( [creator] => Paula Hooper ) [pubdate] => Thu, 28 Apr 2022 22:08:47 +0000 [category] => Lifestyleétionslimaginonsnousutiles [guid] => https://wikileaksisdemocracy.org/?p=30120 [description] => Je ne sais pas pour vous, mais moi depuis très jeune, j’avais envie de me sentir ‘utile’. Je vois bien autour de moi que l’on est nombreux à envier les projets, le mode de vie, ou les carrières des autres, celles de certains proches, celles vues au détour d’un post insta, ou encore celles de ... Read more [content] => Array ( [encoded] =>

Je ne sais pas pour vous, mais moi depuis très jeune, j’avais envie de me sentir ‘utile’. Je vois bien autour de moi que l’on est nombreux à envier les projets, le mode de vie, ou les carrières des autres, celles de certains proches, celles vues au détour d’un post insta, ou encore celles de personnes inspirantes dont certains magazines parlent. On se dit qu’eux font des choses qui ont vraiment de l’impact. A la fois c’est inspirant et à la fois cela nous renvoie à notre “petite vie” comparée à la leur. 

Et ce qui est fou, c’est que l’on passe beaucoup de temps à envier la vie des autres, alors que ces mêmes vies (avec leurs avantages mais AUSSI leurs inconvénients) NE NOUS conviendraient PAS. En réalité, nous sommes dans cette frustration parce que nous sommes TRÈS nombreux à ne pas être conscient de notre propre valeur à nous. Notamment parce que la société aujourd’hui accorde beaucoup de valeur et de reconnaissance à un nombre très restreint de “types de projets”, alors qu’il existe 1001 façons d’avoir UNE ÉNORME VALEUR, et d’être très utile dans ce monde.

Je me souviens d’une amie qui depuis des années était frustrée de ne pas avoir un job “plus gratifiant », elle aurait aimé “briller” un peu plus dans sa carrière. Et après discussion, j’ai compris que cette amie-là, ce qu’elle aimait – et qui était sa plus grande valeur ajoutée – c’était d’organiser des supers activités pour ses enfants, sa famille au sens large et de contribuer à créer une belle fraternité au sein de celle-ci. Ces projets-là étaient un VRAI KIFF pour elle (et un vrai cadeau pour ses enfants et son entourage). Sauf qu’elle continuait de chercher ailleurs la valeur ajoutée qu’elle pourrait avoir dans ce monde, car aux yeux de la société (et donc à ses yeux) “cela n’avait pas assez de valeur”.  Alors qu’évidemment que OUI, on peut briller dans sa vie en étant le pilier de joie et de fraternité de sa famille 🔥. 

À l’identique, un autre de mes amis, Paul, était depuis deux ans “en bilan de compétence” avec l’envie d’avoir un job qui a du sens. En discutant avec lui, il a réalisé que ce qui le faisait vibrer en réalité, c’est de PROFITER de la vie au sens “d’être le mec sympathique, avec qui tu es content d’échanger et de passer un moment de franche rigolade”. Et ça pas de bol, notre société ne dit pas haut et fort que : “On kiff les bons vivants qui nous remettent le sourire aux lèvres et qui nous font passer un moment de légèreté !”.

En prenant conscience de nos énormes valeurs ajoutées, il y a alors comme un DÉCLIC 💥… : on rentre dans un cercle vertueux  :  plus on a conscience de la valeur ajoutée que l’on apporte, plus on a envie de l’utiliser et plus on la montre davantage au grand jour. Et c’est à CE moment LA que la magie s’opère : les autres vont voir toute notre valeur : et l’on obtient alors cette fameuse reconnaissance que la société ne nous accordait pas. C’est alors beaucoup plus efficace (et rapide) que de faire l’inverse : attendre que les autres reconnaissent notre valeur, pour enfin en prendre conscience… 

“Mais alors Paul, pourquoi chercher plus loin ? Le voilà ton bilan de compétence !” Les étincelles que cette idée provoque dans ses yeux, suffisent à comprendre que là était sa voix. 

Et toi, ta ou tes VALEUR(S) AJOUTÉE(S), elles sont où ? 

C’est une question simple, mais qui est source d’un énorme bond dans notre vie quand on y répond. Parce que c’est seulement une fois que l’on a CONSCIENCE de la valeur que l’on a  :

👉 que l’on envie beaucoup moins les autres, de ce qu’il font, ou sont

👉que l’on arrête de poursuivre des objectifs qui ne nous correspondent pas (ou d’être frustré de ne pas trouver la force de poursuivre des objectifs que l’on croit être les nôtres)

👉 que l’on multiplie notre envie d’utiliser cette force et de la mettre au profit des autres. 

👉 que l’on obtient enfin de la reconnaissance !

Et pour nos enfants c’est exactement la même chose. Et prenant nous-même conscience des valeurs ajoutées de notre enfant et en leur montrant en quoi faire ce qu’il aime naturellement faire peut être utile aux autres, on diminue naturellement la pression pour « être bon à l’école” “faire plaisir à machin” “être gentil avec bidule”. Car leurs forces naturelles prendront plus de place et leurs faiblesses (ou plutôt ce qu’il pense être ses faiblesses) paraîtront moins visibles.  

Et si on prenait le temps d’ouvrir les yeux sur nos forces et nos utilités et d’en profiter pour aider notre enfant à faire de même ? 

NB : Si l’idée vous tente, c’est le programme du mois de #Mai 🤩 dans l’appli Cool Parents, une thématique inédite chez CPMHK, qui peut faire une vraie différence dans NOTRE VIE ! Rejoins-nous pour ce mois-ci mais aussi pour tous les autres, car toute l’année dans l’appli Cool Parents, on est plus de 2500 parents à se ressourcer, à se rebooster et à faire des petits pas, qui ont un GRAND impact dans notre vie. 

🚀 UNE ÉQUIPE : tous les Cool parents !

🎯 DÉMARRAGE : le 04/05/2022

📍UN LIEU : l’appli Cool Parents

We would like to say thanks to the writer of this article for this outstanding web content

Et si nous étions plus utiles que nous ne l’imaginons ?

) [summary] => Je ne sais pas pour vous, mais moi depuis très jeune, j’avais envie de me sentir ‘utile’. Je vois bien autour de moi que l’on est nombreux à envier les projets, le mode de vie, ou les carrières des autres, celles de certains proches, celles vues au détour d’un post insta, ou encore celles de ... Read more [atom_content] =>

Je ne sais pas pour vous, mais moi depuis très jeune, j’avais envie de me sentir ‘utile’. Je vois bien autour de moi que l’on est nombreux à envier les projets, le mode de vie, ou les carrières des autres, celles de certains proches, celles vues au détour d’un post insta, ou encore celles de personnes inspirantes dont certains magazines parlent. On se dit qu’eux font des choses qui ont vraiment de l’impact. A la fois c’est inspirant et à la fois cela nous renvoie à notre “petite vie” comparée à la leur. 

Et ce qui est fou, c’est que l’on passe beaucoup de temps à envier la vie des autres, alors que ces mêmes vies (avec leurs avantages mais AUSSI leurs inconvénients) NE NOUS conviendraient PAS. En réalité, nous sommes dans cette frustration parce que nous sommes TRÈS nombreux à ne pas être conscient de notre propre valeur à nous. Notamment parce que la société aujourd’hui accorde beaucoup de valeur et de reconnaissance à un nombre très restreint de “types de projets”, alors qu’il existe 1001 façons d’avoir UNE ÉNORME VALEUR, et d’être très utile dans ce monde.

Je me souviens d’une amie qui depuis des années était frustrée de ne pas avoir un job “plus gratifiant », elle aurait aimé “briller” un peu plus dans sa carrière. Et après discussion, j’ai compris que cette amie-là, ce qu’elle aimait – et qui était sa plus grande valeur ajoutée – c’était d’organiser des supers activités pour ses enfants, sa famille au sens large et de contribuer à créer une belle fraternité au sein de celle-ci. Ces projets-là étaient un VRAI KIFF pour elle (et un vrai cadeau pour ses enfants et son entourage). Sauf qu’elle continuait de chercher ailleurs la valeur ajoutée qu’elle pourrait avoir dans ce monde, car aux yeux de la société (et donc à ses yeux) “cela n’avait pas assez de valeur”.  Alors qu’évidemment que OUI, on peut briller dans sa vie en étant le pilier de joie et de fraternité de sa famille 🔥. 

À l’identique, un autre de mes amis, Paul, était depuis deux ans “en bilan de compétence” avec l’envie d’avoir un job qui a du sens. En discutant avec lui, il a réalisé que ce qui le faisait vibrer en réalité, c’est de PROFITER de la vie au sens “d’être le mec sympathique, avec qui tu es content d’échanger et de passer un moment de franche rigolade”. Et ça pas de bol, notre société ne dit pas haut et fort que : “On kiff les bons vivants qui nous remettent le sourire aux lèvres et qui nous font passer un moment de légèreté !”.

En prenant conscience de nos énormes valeurs ajoutées, il y a alors comme un DÉCLIC 💥… : on rentre dans un cercle vertueux  :  plus on a conscience de la valeur ajoutée que l’on apporte, plus on a envie de l’utiliser et plus on la montre davantage au grand jour. Et c’est à CE moment LA que la magie s’opère : les autres vont voir toute notre valeur : et l’on obtient alors cette fameuse reconnaissance que la société ne nous accordait pas. C’est alors beaucoup plus efficace (et rapide) que de faire l’inverse : attendre que les autres reconnaissent notre valeur, pour enfin en prendre conscience… 

“Mais alors Paul, pourquoi chercher plus loin ? Le voilà ton bilan de compétence !” Les étincelles que cette idée provoque dans ses yeux, suffisent à comprendre que là était sa voix. 

Et toi, ta ou tes VALEUR(S) AJOUTÉE(S), elles sont où ? 

C’est une question simple, mais qui est source d’un énorme bond dans notre vie quand on y répond. Parce que c’est seulement une fois que l’on a CONSCIENCE de la valeur que l’on a  :

👉 que l’on envie beaucoup moins les autres, de ce qu’il font, ou sont

👉que l’on arrête de poursuivre des objectifs qui ne nous correspondent pas (ou d’être frustré de ne pas trouver la force de poursuivre des objectifs que l’on croit être les nôtres)

👉 que l’on multiplie notre envie d’utiliser cette force et de la mettre au profit des autres. 

👉 que l’on obtient enfin de la reconnaissance !

Et pour nos enfants c’est exactement la même chose. Et prenant nous-même conscience des valeurs ajoutées de notre enfant et en leur montrant en quoi faire ce qu’il aime naturellement faire peut être utile aux autres, on diminue naturellement la pression pour « être bon à l’école” “faire plaisir à machin” “être gentil avec bidule”. Car leurs forces naturelles prendront plus de place et leurs faiblesses (ou plutôt ce qu’il pense être ses faiblesses) paraîtront moins visibles.  

Et si on prenait le temps d’ouvrir les yeux sur nos forces et nos utilités et d’en profiter pour aider notre enfant à faire de même ? 

NB : Si l’idée vous tente, c’est le programme du mois de #Mai 🤩 dans l’appli Cool Parents, une thématique inédite chez CPMHK, qui peut faire une vraie différence dans NOTRE VIE ! Rejoins-nous pour ce mois-ci mais aussi pour tous les autres, car toute l’année dans l’appli Cool Parents, on est plus de 2500 parents à se ressourcer, à se rebooster et à faire des petits pas, qui ont un GRAND impact dans notre vie. 

🚀 UNE ÉQUIPE : tous les Cool parents !

🎯 DÉMARRAGE : le 04/05/2022

📍UN LIEU : l’appli Cool Parents

We would like to say thanks to the writer of this article for this outstanding web content

Et si nous étions plus utiles que nous ne l’imaginons ?

) [8] => Array ( [title] => Jennifer Lopez y Ben Affleck: cómo se sienten los hijos del actor con su futura boda [link] => https://wikileaksisdemocracy.org/celebrity/jennifer-lopez-y-ben-affleck-como-se-sienten-los-hijos-del-actor-con-su-futura-boda/ [dc] => Array ( [creator] => Sally Scully ) [pubdate] => Thu, 28 Apr 2022 21:55:34 +0000 [category] => CelebrityactorAffleckBenbodaComodelfuturahijosJenniferLopezlossienten [guid] => https://wikileaksisdemocracy.org/?p=30114 [description] => Jennifer Lopez y Ben Affleck está comprometidos nuevamente luego que el actor le entregara un anillo con diamante verde a 20 años de la primera vez que le pidió que fuera su esposa. Ahora que se sabe que están buscando una mansión para convertirla en su ‘nidito de amor’ y que planean formar una “familia ... Read more [content] => Array ( [encoded] =>

Jennifer Lopez y Ben Affleck está comprometidos nuevamente luego que el actor le entregara un anillo con diamante verde a 20 años de la primera vez que le pidió que fuera su esposa. Ahora que se sabe que están buscando una mansión para convertirla en su ‘nidito de amor’ y que planean formar una “familia mezclada” con los hijos que tuvieron en sus anteriores matrimonios, ¿qué es lo que opinan los pequeños de Jennifer Garner sobre la novia de su padre?.

MÁS INFORMACIÓN | Jennifer Lopez presume su anillo de compromiso: qué hizo Ben Affleck en la pedida de mano

Una fuente cercana a la pareja aseguró a que las celebridades no tienen en mente traer un niño al mundo, sino que su prioridad es dedicarse a educar correctamente a los que ya tienen. Y es que JLo es madre de Emme y Max, los mellizos de su matrimonio con Marc Anthony; y Violet, Seraphina y Samuel, nacieron del amor de Ben y la actriz de ‘Si tuviera 30′ o ‘The Adam Project’.

“No quieren nuevos hijos, ambos ya pasaron esa parte de sus vidas (…) Lo importante es que la conexión de Jennifer con los hijos de Ben sea muy estrecha, y esa es una de las razones que le han llevado a aceptar de buena gana la situación (…) Ben y JLo regresaron a la vida del otro con una camada completa de hijos, y son muy bendecidos porque todos son realmente buenos niños. Ahora se están enfocando en criarlos para que sean buenos adultos y la fiesta de cinco es suficiente para ellos”, precisó el informante.

Qué opinan los hijos de Ben Affleck sobre JLo

Esta misma fuente también dijo que Jennifer Lopez es muy querida por los hijos de su futuro esposo y que la química es mayor con el más pequeño, Samuel.

“Jennifer Lopez es amada por todos los hijos de Ben, pero definitivamente tiene un vínculo especial con Samuel. Porque Samuel es el más joven de los cinco hijos y es el bebé del grupo, por así decirlo (…) Cuando Ben y Jen (Garner) se separaron en 2015, Samuel era demasiado pequeño para recordar nada de eso, pero siempre ha crecido con dos padres amorosos (…) JLo dice que Samuel se parece mucho a su padre. Ella trata a todos sus hijos como si fueran suyos, siempre respetando el hecho de que Jen es su madre”.

Cómo fue la pedida de mano de JLo

La propia Jennifer Lopez se encargó de revelar los detalles ocultos de su mágica noche y cómo 20 años después, quien más ama la sorprendió con un diamante verde, su color de la suerte: “¿Alguna vez imaginaste que tu mayor sueño podría hacerse realidad?”.

“El sábado por la noche, mientras estaba en mi lugar favorito en la tierra (en el baño de burbujas), mi hermoso amor se arrodilló y me propuso matrimonio (…) Me tomó completamente por sorpresa, así que le miré fijamente a los ojos, riendo y llorando al mismo tiempo, haciendo lo posible para comprender el hecho de que 20 años después, todo volviera a suceder. Me quedé literalmente sin palabras. Entonces me preguntó… ‘¿Eso quiere decir que sí?’”, escribió JLo en una carta a sus fans difundida en su página oficial.

La historia de Bennifer 2021

Jennifer Lopez y Ben Affleck empezaron a verse de nuevo el 2021, después de que la autora de éxitos como “Jenny from the Block” terminara su compromiso con la exestrella de los Yankees Alex Rodríguez y que el actor y productor acabara su relación con la actriz española Ana de Armas.

La pareja, apodada “Bennifer 2021″, se ha dejado ver desde entonces en alfombras rojas y paseos en público por el mundo, solos o acompañados de sus respectivos hijos: Jennifer Lopez tuvo dos con su exesposo, el cantante Marc Anthony; y Ben Affleck tres con su expareja, la actriz Jennifer Garner.

JLo, de 52 años, y Ben Affleck, de 49, comenzaron a salir a mitad de 2002 y se comprometieron ese mismo año, pero pospusieron la boda y finalmente la cancelaron en 2004, aunque han asegurado que su amistad se mantuvo a lo largo de los años antes de que se dieran una segunda oportunidad.

We would like to thank the writer of this short article for this incredible web content

Jennifer Lopez y Ben Affleck: cómo se sienten los hijos del actor con su futura boda

) [summary] => Jennifer Lopez y Ben Affleck está comprometidos nuevamente luego que el actor le entregara un anillo con diamante verde a 20 años de la primera vez que le pidió que fuera su esposa. Ahora que se sabe que están buscando una mansión para convertirla en su ‘nidito de amor’ y que planean formar una “familia ... Read more [atom_content] =>

Jennifer Lopez y Ben Affleck está comprometidos nuevamente luego que el actor le entregara un anillo con diamante verde a 20 años de la primera vez que le pidió que fuera su esposa. Ahora que se sabe que están buscando una mansión para convertirla en su ‘nidito de amor’ y que planean formar una “familia mezclada” con los hijos que tuvieron en sus anteriores matrimonios, ¿qué es lo que opinan los pequeños de Jennifer Garner sobre la novia de su padre?.

MÁS INFORMACIÓN | Jennifer Lopez presume su anillo de compromiso: qué hizo Ben Affleck en la pedida de mano

Una fuente cercana a la pareja aseguró a que las celebridades no tienen en mente traer un niño al mundo, sino que su prioridad es dedicarse a educar correctamente a los que ya tienen. Y es que JLo es madre de Emme y Max, los mellizos de su matrimonio con Marc Anthony; y Violet, Seraphina y Samuel, nacieron del amor de Ben y la actriz de ‘Si tuviera 30′ o ‘The Adam Project’.

“No quieren nuevos hijos, ambos ya pasaron esa parte de sus vidas (…) Lo importante es que la conexión de Jennifer con los hijos de Ben sea muy estrecha, y esa es una de las razones que le han llevado a aceptar de buena gana la situación (…) Ben y JLo regresaron a la vida del otro con una camada completa de hijos, y son muy bendecidos porque todos son realmente buenos niños. Ahora se están enfocando en criarlos para que sean buenos adultos y la fiesta de cinco es suficiente para ellos”, precisó el informante.

Qué opinan los hijos de Ben Affleck sobre JLo

Esta misma fuente también dijo que Jennifer Lopez es muy querida por los hijos de su futuro esposo y que la química es mayor con el más pequeño, Samuel.

“Jennifer Lopez es amada por todos los hijos de Ben, pero definitivamente tiene un vínculo especial con Samuel. Porque Samuel es el más joven de los cinco hijos y es el bebé del grupo, por así decirlo (…) Cuando Ben y Jen (Garner) se separaron en 2015, Samuel era demasiado pequeño para recordar nada de eso, pero siempre ha crecido con dos padres amorosos (…) JLo dice que Samuel se parece mucho a su padre. Ella trata a todos sus hijos como si fueran suyos, siempre respetando el hecho de que Jen es su madre”.

Cómo fue la pedida de mano de JLo

La propia Jennifer Lopez se encargó de revelar los detalles ocultos de su mágica noche y cómo 20 años después, quien más ama la sorprendió con un diamante verde, su color de la suerte: “¿Alguna vez imaginaste que tu mayor sueño podría hacerse realidad?”.

“El sábado por la noche, mientras estaba en mi lugar favorito en la tierra (en el baño de burbujas), mi hermoso amor se arrodilló y me propuso matrimonio (…) Me tomó completamente por sorpresa, así que le miré fijamente a los ojos, riendo y llorando al mismo tiempo, haciendo lo posible para comprender el hecho de que 20 años después, todo volviera a suceder. Me quedé literalmente sin palabras. Entonces me preguntó… ‘¿Eso quiere decir que sí?’”, escribió JLo en una carta a sus fans difundida en su página oficial.

La historia de Bennifer 2021

Jennifer Lopez y Ben Affleck empezaron a verse de nuevo el 2021, después de que la autora de éxitos como “Jenny from the Block” terminara su compromiso con la exestrella de los Yankees Alex Rodríguez y que el actor y productor acabara su relación con la actriz española Ana de Armas.

La pareja, apodada “Bennifer 2021″, se ha dejado ver desde entonces en alfombras rojas y paseos en público por el mundo, solos o acompañados de sus respectivos hijos: Jennifer Lopez tuvo dos con su exesposo, el cantante Marc Anthony; y Ben Affleck tres con su expareja, la actriz Jennifer Garner.

JLo, de 52 años, y Ben Affleck, de 49, comenzaron a salir a mitad de 2002 y se comprometieron ese mismo año, pero pospusieron la boda y finalmente la cancelaron en 2004, aunque han asegurado que su amistad se mantuvo a lo largo de los años antes de que se dieran una segunda oportunidad.

We would like to thank the writer of this short article for this incredible web content

Jennifer Lopez y Ben Affleck: cómo se sienten los hijos del actor con su futura boda

) [9] => Array ( [title] => Il Mago di Oz, in vendita all’asta il famoso abito di Judy Garland [link] => https://wikileaksisdemocracy.org/shows/il-mago-di-oz-in-vendita-allasta-il-famoso-abito-di-judy-garland/ [dc] => Array ( [creator] => David Lonit ) [pubdate] => Thu, 28 Apr 2022 21:51:27 +0000 [category] => ShowsabitoallastafamosoGarlandJudyMagovendita [guid] => https://wikileaksisdemocracy.org/?p=30108 [description] => Somewhere over the rainbow. Da qualche parte oltre l’arcobaleno. Proprio così recita la colonna sonora del film ‘Il Mago di Oz‘ e proprio lì doveva essersi cacciato per tutti questi anni il celebre abito bianco e celeste di Dorothy Gale alias Judy Garland.   Leggi anche > Disney+, tutte le serie tv in uscita a ... Read more [content] => Array ( [encoded] =>



Somewhere over the rainbow. Da qualche parte oltre l’arcobaleno. Proprio così recita la colonna sonora del film ‘Il Mago di Oz‘ e proprio lì doveva essersi cacciato per tutti questi anni il celebre abito bianco e celeste di Dorothy Gale alias Judy Garland.

 

Leggi anche > Disney+, tutte le serie tv in uscita a maggio 2022

 

 

Il Mago di Oz, in vendita all’asta il famoso abito di Judy Garland

Dopo oltre 80 anni dall’uscita della pellicola sul grande schermo nel 1939, il vestito che si credeva smarrito per sempre è stato ritrovato e il prossimo mese sarà venduto all’asta. A renderlo noto è il magazine Town&Country che ricostruisce l’avventurosa vicenda di questo costume di scena e del suo fortunoso ritrovamento lo scorso anno.

Come racconta la testata, la storia incomincia nel 1973 quando l’attrice hollywoodiana Mercedes McCambridge decide di donare alla Catholic University of America (CUA) il celebre vestito. L’artista era quasi coetanea di Judy e le due devono essere state presumibilmente amiche, ma non è chiaro come sia entrata in possesso dell’indumento. Tuttavia a partire dal 1980 si perde ogni traccia del prezioso abito, che salta fuori del tutto casualmente solo dopo 40 anni, nel 2021.

«Avevo guardato nei nostri archivi, armadi, ecc. senza alcun risultato» ha spiegato il docente Matt Ripa. «[Io] supponevo che fosse una “leggenda”. Il nostro edificio è in fase di ristrutturazione e aggiornamenti, quindi stavo pulendo il mio ufficio per prepararmi. Ho notato in cima alle cassette postali della facoltà un sacchetto della spazzatura e ho chiesto al mio collega di consegnarmelo. Sul cestino c’era un biglietto che diceva che qualcuno aveva trovato “questo” nel suo ufficio e che doveva averlo spostato quando si era trasferito. Ero curioso di sapere cosa c’era dentro: ho aperto il sacchetto della spazzatura, dentro c’era una scatola da scarpe e all’interno della scatola delle scarpe c’era il vestito! Non potevo crederci».

Presentato alla casa d’aste Bonhams Classic Hollywood: Film and Television sale di Los Angeles per la vendita, l’abito è stato stimato tra gli 800mila dollari e 1,2 milioni di dollari. Secondo Bonhams, il vestito è stato «scelto per una specifica scena dell’amato film, vale a dire quando Dorothy affronta la Strega Malvagia dell’Ovest [interpretata da Margaret Hamilton, ndr] nel Castello delle Streghe».

Quando si terrà l’asta

«Scoprire questo abito storico è stato un momento memorabile per la Catholic University of America e siamo orgogliosi di presentarlo all’asta, in modo che il prossimo collezionista possa possedere un pezzo di storia» ha detto Jacqueline J. Leary-Warsaw, preside della Benjamin T. Rome School of Music, Drama, and Art, in un comunicato stampa. Attualmente l’abito “Dorothy” di Judy Garland è in mostra al Bonhams di New York e dal 20 al 24 maggio sarà visibile al Bonhams di Los Angeles prima che venga messo all’asta il 24 maggio.

Separarsi da questo pezzo di storia del cinema è una sensazione «dolceamara», spiega la professoressa, ma «il ricavato contribuirà a sostenere la formazione delle generazioni future per le carriere professionali nel teatro» a beneficio del Dipartimento Drammatico della CUA. E chissà che proprio il denaro raccolto non contribuisca a finanziare gli studi della futura Judy Garland!




Ultimo aggiornamento: Giovedì 28 Aprile 2022, 22:27



© RIPRODUZIONE RISERVATA

We wish to thank the writer of this post for this outstanding content

Il Mago di Oz, in vendita all’asta il famoso abito di Judy Garland

) [summary] => Somewhere over the rainbow. Da qualche parte oltre l’arcobaleno. Proprio così recita la colonna sonora del film ‘Il Mago di Oz‘ e proprio lì doveva essersi cacciato per tutti questi anni il celebre abito bianco e celeste di Dorothy Gale alias Judy Garland.   Leggi anche > Disney+, tutte le serie tv in uscita a ... Read more [atom_content] =>



Somewhere over the rainbow. Da qualche parte oltre l’arcobaleno. Proprio così recita la colonna sonora del film ‘Il Mago di Oz‘ e proprio lì doveva essersi cacciato per tutti questi anni il celebre abito bianco e celeste di Dorothy Gale alias Judy Garland.

 

Leggi anche > Disney+, tutte le serie tv in uscita a maggio 2022

 

 

Il Mago di Oz, in vendita all’asta il famoso abito di Judy Garland

Dopo oltre 80 anni dall’uscita della pellicola sul grande schermo nel 1939, il vestito che si credeva smarrito per sempre è stato ritrovato e il prossimo mese sarà venduto all’asta. A renderlo noto è il magazine Town&Country che ricostruisce l’avventurosa vicenda di questo costume di scena e del suo fortunoso ritrovamento lo scorso anno.

Come racconta la testata, la storia incomincia nel 1973 quando l’attrice hollywoodiana Mercedes McCambridge decide di donare alla Catholic University of America (CUA) il celebre vestito. L’artista era quasi coetanea di Judy e le due devono essere state presumibilmente amiche, ma non è chiaro come sia entrata in possesso dell’indumento. Tuttavia a partire dal 1980 si perde ogni traccia del prezioso abito, che salta fuori del tutto casualmente solo dopo 40 anni, nel 2021.

«Avevo guardato nei nostri archivi, armadi, ecc. senza alcun risultato» ha spiegato il docente Matt Ripa. «[Io] supponevo che fosse una “leggenda”. Il nostro edificio è in fase di ristrutturazione e aggiornamenti, quindi stavo pulendo il mio ufficio per prepararmi. Ho notato in cima alle cassette postali della facoltà un sacchetto della spazzatura e ho chiesto al mio collega di consegnarmelo. Sul cestino c’era un biglietto che diceva che qualcuno aveva trovato “questo” nel suo ufficio e che doveva averlo spostato quando si era trasferito. Ero curioso di sapere cosa c’era dentro: ho aperto il sacchetto della spazzatura, dentro c’era una scatola da scarpe e all’interno della scatola delle scarpe c’era il vestito! Non potevo crederci».

Presentato alla casa d’aste Bonhams Classic Hollywood: Film and Television sale di Los Angeles per la vendita, l’abito è stato stimato tra gli 800mila dollari e 1,2 milioni di dollari. Secondo Bonhams, il vestito è stato «scelto per una specifica scena dell’amato film, vale a dire quando Dorothy affronta la Strega Malvagia dell’Ovest [interpretata da Margaret Hamilton, ndr] nel Castello delle Streghe».

Quando si terrà l’asta

«Scoprire questo abito storico è stato un momento memorabile per la Catholic University of America e siamo orgogliosi di presentarlo all’asta, in modo che il prossimo collezionista possa possedere un pezzo di storia» ha detto Jacqueline J. Leary-Warsaw, preside della Benjamin T. Rome School of Music, Drama, and Art, in un comunicato stampa. Attualmente l’abito “Dorothy” di Judy Garland è in mostra al Bonhams di New York e dal 20 al 24 maggio sarà visibile al Bonhams di Los Angeles prima che venga messo all’asta il 24 maggio.

Separarsi da questo pezzo di storia del cinema è una sensazione «dolceamara», spiega la professoressa, ma «il ricavato contribuirà a sostenere la formazione delle generazioni future per le carriere professionali nel teatro» a beneficio del Dipartimento Drammatico della CUA. E chissà che proprio il denaro raccolto non contribuisca a finanziare gli studi della futura Judy Garland!




Ultimo aggiornamento: Giovedì 28 Aprile 2022, 22:27



© RIPRODUZIONE RISERVATA

We wish to thank the writer of this post for this outstanding content

Il Mago di Oz, in vendita all’asta il famoso abito di Judy Garland

) ) [channel] => Array ( [title] => Wikileaksisdemocracy [link] => https://wikileaksisdemocracy.org [lastbuilddate] => Fri, 29 Apr 2022 04:04:53 +0000 [language] => en-US [sy] => Array ( [updateperiod] => hourly [updatefrequency] => 1 ) [generator] => https://wordpress.org/?v=5.9.3 [tagline] => ) [textinput] => Array ( ) [image] => Array ( ) [feed_type] => RSS [feed_version] => 2.0 [stack] => Array ( ) [inchannel] => [initem] => [incontent] => [intextinput] => [inimage] => [current_field] => [current_namespace] => [ERROR] => [_CONTENT_CONSTRUCTS] => Array ( [0] => content [1] => summary [2] => info [3] => title [4] => tagline [5] => copyright ) [last_modified] => Fri, 29 Apr 2022 04:04:53 GMT [etag] => W/"ee3af829a3115cc15432c40246abe309-gzip" )